Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men.

Abstract

OBJECTIVE:

To investigate the association between biochemical markers of bone, cartilage, and synovial turnover with the presence and severity of knee osteoarthritis (OA) in men.

METHODS:

176 men aged 59-70 years from the MRC Hertfordshire Cohort were studied. Weightbearing anteroposterior and lateral semiflexed radiographs were taken of both knees. A lifestyle questionnaire including basic demographic details and a questionnaire detailing knee pain was completed. This random sample was stratified based on the Kellgren and Lawrence (K&L) score, and the following biochemical markers were analysed: serum osteocalcin, serum C-terminal crosslinked telopeptide of type I collagen (CTX-I), urinary C-terminal crosslinked telopeptide of type II collagen (CTX-II), and urinary glucosyl-galactosyl-pyridinoline (Glc-Gal-Pyd).

RESULTS:

Age, body mass index (BMI), social class, smoking, and alcohol consumption were similar across K&L grades. Only one subject had a grade 4 K&L score, and was amalgamated with grade 3 subjects. A strong significant association was found between the presence of knee OA and urinary CTX-II and urinary Glc-Gal-Pyd (p=0.0001 and p=0.009), which persisted after adjustment for age and BMI. A significant positive association was also found between urinary CTX-II and urinary Glc-Gal-Pyd and the severity of K&L grade, joint space narrowing, and osteophytes scores, which persisted after adjustment for age and BMI. No associations between the presence and severity of knee OA were found for serum CTX-I or serum osteocalcin.

CONCLUSIONS:

Urinary CTX-II and Glc-Gal-Pyd, but not systemic markers of bone turnover, are strongly associated with disease severity and the presence of OA at the tibiofemoral and patellofemoral joints in men.

• Authors: K M Jordan, H E Syddall, P Garnero, E Gineyts, E M Dennison, A A Sayer, P D Delmas, C Cooper, N K Arden
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 65 Issue 7 Pg. 871-7 (Jul 2006) ISSN: 0003-4967 [Print] England
• PMID: 16284096 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Collagen Type I
• Glycosides
• Peptides
• collagen type I trimeric cross-linked peptide
• Osteocalcin

Topics

• Aged
• Biomarkers (urine)
• Bone Remodeling
• Cartilage, Articular (pathology)
• Collagen Type I (urine)
• Glycosides (urine)
• Humans
• Knee Joint (diagnostic imaging)
• Male
• Middle Aged
• Osteoarthritis (diagnostic imaging, pathology, urine)
• Osteocalcin (urine)
• Peptides (urine)
• Radiography
• Synovitis (urine)