Healing promoting actions of
Rhinax, a multiconstituent
herbal preparation, was investigated in chronic gastric and
duodenal ulcer models induced by
acetic acid in rats and the effects were compared with those of
famotidine by gross of histological evaluation.
Rhinax markedly promoted the well balanced healing of
gastric ulcer at oral does of 25-100 mg/kg x 2 /day, as evidenced by the reduction of
ulcer, regeneration of mucosa and proliferation of connecitve tissue.
Rhinax caused an increase in gastric mucosa secretion in all the regenerated mucosa around the
gastric ulcers.
Famotidine failed to promote the healing of
gastric ulcers at 100 mg/kg x 2/ day p.o.
Rhinax also significantly accelerated the healing of
acetic acid -induced
duodenal ulcers as well
famotidine. These results indicate that
Rhinax is characterised by a potent promoting action on the healing of chronic
ulcers, suggesting that the increase in gastric mucus secretion might be associated with the antiulcer action of
Rhinax in rats.