The aims of this study were to report experience in patients with
organophosphate poisoning (
OPP) and to discuss the potential role for
hemoperfusion (HP) in the management of severe
OPP. At the emergency service of a university hospital, 52 patients with acute
OPP were included in this retrospective study. The patients were divided into 2 groups (Group 1, severe
poisoning, n = 25; and Group 2, mild
poisoning, n = 27). All patients with mild
OPP survived. Seven patients (28%) of the 25 with severe
OPP died. This study supports previous data documenting that HP is unnecessary in the management of mild
OPP. Although there was not a control group (severe
poisoning without HP treatment) in this study, experience suggests that HP can be useful in severe cases. Reports from centers having experience with severe
OPP can help clarify this controversial issue. Randomized controlled (prospective) studies investigating the possible beneficial effects of HP on patient survival in patients with severe
OPP with control group are needed.