Abstract |
GABA(B) receptor1 ( GABA(B)R1) gene is one of the susceptibility genes for temporal lobe epilepsy (TLE). Recently, it is reported that the GABA(B)R1 polymorphism (G1465A) conferred a highly increased susceptibility to TLE. We performed a case-control study to confirm the findings. The study included a total of 112 nonlesional TLE patients and 124 controls of Chinese ancestry. Our study did not show any polymorphism in this locus, and suggested this polymorphism may not be a strong susceptibility factor for TLE among Chinese population.
|
Authors | Liankun Ren, Liri Jin, Boyu Zhang, Yanbin Jia, Liwen Wu, Yan Shen |
Journal | Seizure
(Seizure)
Vol. 14
Issue 8
Pg. 611-3
(Dec 2005)
ISSN: 1059-1311 [Print] England |
PMID | 16278087
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Case-Control Studies
- China
(epidemiology)
- Epilepsy, Temporal Lobe
(epidemiology, genetics)
- Female
- Genetic Variation
- Humans
- Male
- Polymorphism, Genetic
- Population Groups
- Receptors, GABA-B
(genetics)
|