Analgesic efficacy of aceclofenac after surgical extraction of impacted lower third molars.

The analgesic efficacy of aceclofenac in the control of pain after surgical extraction of impacted mandibular third molars was compared with its preoperative administration. Two groups of 20 patients each were medicated with 2 tablets of 100 mg aceclofenac taken orally either 1h before surgery or in the early postoperative period. All surgeries were performed by the same surgeon and the surgical technique was the same for all patients. Pain was assessed with a Visual Analogue Scale and a 0-4 Scale, as well as by counting the number of analgesic drug tablets taken after the surgery. Patients in the preoperative group took fewer tablets postoperatively and had a lower pain score both in the Visual Analogue Scale and the 0-4 Scale. This difference, however, was statistically significant only at 6h after surgery, which is the time of maximum pain for this surgical procedure. Aceclofenac was more efficient in controlling pain when administered before the surgery.
AuthorsP V Presser Lima, V Fontanella
JournalInternational journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 35 Issue 6 Pg. 518-21 (Jun 2006) ISSN: 0901-5027 [Print] Denmark
PMID16278069 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Tablets
  • Diclofenac
  • aceclofenac
  • Administration, Oral
  • Adult
  • Analgesics (administration & dosage, therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
  • Diclofenac (administration & dosage, analogs & derivatives, therapeutic use)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Mandible (surgery)
  • Molar, Third (surgery)
  • Pain Measurement
  • Pain, Postoperative (prevention & control)
  • Premedication
  • Tablets
  • Time Factors
  • Tooth Extraction (adverse effects)
  • Tooth, Impacted (surgery)

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