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Residue depletion of eprinomectin in bovine tissues after subcutaneous administration.

Abstract
A study of the tissue depletion of eprinomectin (EPR) subcutaneously administered to cattle at a dose of 500 mg per kg of body weight was carried out. EPR concentrations were determined in muscle, liver, kidney, and fat. Twenty-four parasite-free cross cattle were treated with the EPR injectable oil formulation. Three treated animals (two males and one female) were selected randomly to be sacrificed at 1, 3, 7, 14, 21, 28, 42, and 56 days withdrawal after injection. EPR residue concentrations were determined using HPLC with fluorescence detection. Muscle samples showed the lowest EPR concentrations throughout the study period. The highest EPR concentrations at all sampling times were measured in liver tissue, indicating that liver is a target tissue for EPR. EPR concentrations in all of the tissues analyzed were below the accepted maximum residue limits recommended by the European Union at 8 days posttreatment.
AuthorsHaiyang Jiang, Xiaolin Hou, Shuangyang Ding, Sijun Zhao, Jihong He, Jianzhong Shen
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 53 Issue 23 Pg. 9288-92 (Nov 16 2005) ISSN: 0021-8561 [Print] United States
PMID16277435 (Publication Type: Journal Article)
Chemical References
  • Anthelmintics
  • Ivermectin
  • eprinomectin
Topics
  • Adipose Tissue (chemistry)
  • Animals
  • Anthelmintics (administration & dosage, pharmacokinetics)
  • Cattle (metabolism)
  • Chromatography, High Pressure Liquid
  • Drug Residues (analysis)
  • Injections, Subcutaneous
  • Ivermectin (administration & dosage, analogs & derivatives, analysis, pharmacokinetics)
  • Kidney (chemistry)
  • Liver (chemistry)
  • Muscles (chemistry)

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