Abstract | OBJECTIVE: DESIGN: Prospective, randomized, experimental. SETTING: Physiology experiment laboratory. SUBJECTS: Male Sprague-Dawley rats, weighing 250-300 g. INTERVENTIONS: All groups (n = 8 each) underwent femoral artery and vein catheterization. The animals in the TR, SAL, SAL/ BIC/MAN, and HSD groups received an infusion of 2 mL of autologous muscle extract for 60 mins. After autologous muscle extract infusion, the SAL and HSD groups received 30 mL/kg 0.9% saline for 30 mins or 4 mL/kg HSD for 5 mins, respectively. The SAL/ BIC/MAN group received 30 mL/kg 0.9% saline for 30 mins plus a bolus of 1 g/kg mannitol and a bolus of 2 mEq/kg sodium bicarbonate diluted in 1 mL of saline. At 2 hrs of autologous muscle extract infusion, erythrocyte flows in liver and kidney were measured by using a laser Doppler flowmeter. Then, blood samples and kidney and liver biopsies were taken to measure levels of glutathione and malondialdehyde. MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS:
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Authors | Halil Ozgüç, Nevzat Kahveci, Sule Akköse, Zehra Serdar, Veysel Balci, Ozgür Ocak |
Journal | Critical care medicine
(Crit Care Med)
Vol. 33
Issue 11
Pg. 2579-86
(Nov 2005)
ISSN: 0090-3493 [Print] United States |
PMID | 16276183
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dextrans
- Drug Combinations
- Rehydration Solutions
- hypertonic saline-dextran solution
- Mannitol
- Sodium Chloride
- Malondialdehyde
- Sodium Bicarbonate
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Topics |
- Acid-Base Equilibrium
(drug effects)
- Animals
- Blood Pressure
(drug effects)
- Dextrans
(therapeutic use)
- Drug Combinations
- Kidney
(blood supply)
- Liver
(blood supply)
- Male
- Malondialdehyde
(blood, metabolism)
- Mannitol
(administration & dosage, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Rehydration Solutions
(therapeutic use)
- Resuscitation
(methods)
- Rhabdomyolysis
(therapy)
- Sodium Bicarbonate
(administration & dosage, therapeutic use)
- Sodium Chloride
(administration & dosage, therapeutic use)
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