Abstract | UNLABELLED:
Cancer pain is a significant clinical problem because it is the first symptom of disease in 20% to 50% of all cancer patients, and 75% to 90% of patients with advanced or terminal cancer must cope with chronic pain syndromes related to failed treatment and/or tumor progression. One of the most difficult to treat cancer pains is metastatic invasion of the skeleton that can generate ongoing and bone breakthrough pain, which represents one of the most debilitating cancer-related events. Because bradykinin has been shown to be released in response to tissue injury and plays a significant role in driving acute and chronic inflammatory pain, we focused on bradykinin antagonists in a model of bone cancer pain. In our model of bone cancer, which involves the injection and confinement of 2472 sarcoma cells to the mouse femur, pharmacologic blockade of the bradykinin B1 receptor is effective in reducing pain-related behaviors at both early and advanced stages of bone cancer. PERSPECTIVE:
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Authors | Molly A Sevcik, Joseph R Ghilardi, Kyle G Halvorson, Theodore H Lindsay, Kazufumi Kubota, Patrick W Mantyh |
Journal | The journal of pain
(J Pain)
Vol. 6
Issue 11
Pg. 771-5
(Nov 2005)
ISSN: 1526-5900 [Print] United States |
PMID | 16275602
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Bradykinin B1 Receptor Antagonists
- bradykinin, Leu(8)-des-Arg(9)-
- Bradykinin
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Topics |
- Animals
- Bone Neoplasms
(complications)
- Bradykinin
(analogs & derivatives, pharmacology)
- Bradykinin B1 Receptor Antagonists
- Injections, Subcutaneous
- Male
- Mice
- Mice, Inbred C3H
- Neoplasm Transplantation
- Pain
(drug therapy, etiology)
- Sarcoma
(complications)
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