Genetics of skin appendage neoplasms and related syndromes.

Abstract

In the past decade the molecular basis of many inherited syndromes has been unravelled. This article reviews the clinical and genetic aspects of inherited syndromes that are characterised by skin appendage neoplasms, including Cowden syndrome, Birt-Hogg-Dube syndrome, naevoid basal cell carcinoma syndrome, generalised basaloid follicular hamartoma syndrome, Bazex syndrome, Brooke-Spiegler syndrome, familial cylindromatosis, multiple familial trichoepitheliomas, and Muir-Torre syndrome.

• Authors: D A Lee, M E Grossman, P Schneiderman, J T Celebi
• Journal: Journal of medical genetics (J Med Genet) Vol. 42 Issue 11 Pg. 811-9 (Nov 2005) ISSN: 1468-6244 [Electronic] England
• PMID: 16272260 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Topics

• Carcinoma, Skin Appendage (genetics, pathology)
• Female
• Genetic Linkage
• Genetic Predisposition to Disease
• Humans
• Male
• Neoplastic Syndromes, Hereditary (genetics)
• Skin Neoplasms (genetics, pathology)
• Syndrome