Is the paraneoplastic syndrome of inappropriate antidiuretic hormone secretion in lung cancer always attributable to the small cell variety?

Abstract

The syndrome of inappropriate antidiuretic hormone (SIADH) secretion is a well recognised paraneoplastic phenomenon and the vast majority are associated with small cell lung carcinoma. Rarely however, the non-small cell variety can sometimes be responsible and this report describes such an occurrence. Uniquely in this case, after chemotherapy the paraneoplastic SIADH improved in parallel with a tumour response and this has not been reported previously.

• Authors: L M Tho, D R Ferry
• Journal: Postgraduate medical journal (Postgrad Med J) Vol. 81 Issue 961 Pg. e17 (Nov 2005) ISSN: 1469-0756 [Electronic] England
• PMID: 16272226 (Publication Type: Journal Article)

Chemical References

• Mitomycin
• Cisplatin
• Ifosfamide

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carcinoma, Non-Small-Cell Lung (complications, diagnostic imaging, drug therapy)
• Cisplatin (administration & dosage)
• Humans
• Ifosfamide (administration & dosage)
• Inappropriate ADH Syndrome (etiology)
• Lung Neoplasms (complications, diagnostic imaging, drug therapy)
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Paraneoplastic Syndromes (diagnostic imaging, drug therapy, etiology)
• Radiography