Determination of iodine concentration in urine by isotope dilution analysis and thyroid volume of school children in the west coast of Turkey after mandatory salt iodization.

Abstract

OBJECTIVE:

This study was designed to evaluate iodine deficiency status in children 6-12 years in the west coast (Aegean Region) of Turkey after 5 years of mandatory iodine prophylaxis. A total of 2300 children from 72 populations (rural and urban area) were evaluated with urinary iodine excretion and thyroid volume.

DESIGN:

Cross-sectional, observational study designed and performed according to surveillance methods for iodine deficiency disease (IDD) prevalence recommended by WHO/UNICEF/ICCIDD.

SUBJECTS:

The study population consisted of 2300 school children age ranging from 6 to 12 years. The children were selected by multiple stage randomization from 91 primary schools of 76 zones (91 clusters). Information about the use of iodized salt was obtained from the families.

MEASUREMENTS:

Data on the following were collected: birth date, sex, weight, height, thyroid size by palpation and ultrasonography; and urinary iodine by isotope dilution analysis method. Thyroid volumes above 97th percentile according to the WHO/ICCIDD by age and body surface area (BSA) were accepted as goitre.

RESULTS:

Iodized salt consumption was 51.7%. The prevalence of goitre determined by palpation was 12.1% and by ultrasound based on BSA and age were 9.8% and 5.5%, respectively. Median urinary iodine was 53 (2-142) microg/l.

CONCLUSION:

Mild to severe degree of iodine deficiency was detected in the west coast of Turkey.

• Authors: Sükran Darcan, Perihan Unak, Osman Yalman, Fatma Yurt Lambrecht, F Zümrüt Biber, Damla Göksen, Mahmut Coker
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 63 Issue 5 Pg. 543-8 (Nov 2005) ISSN: 0300-0664 [Print] England
• PMID: 16268807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Sodium Chloride, Dietary
• iodized salt
• Iodine

Topics

• Chi-Square Distribution
• Child
• Cross-Sectional Studies
• Female
• Goiter, Endemic (diagnosis, epidemiology, prevention & control)
• Humans
• Indicator Dilution Techniques
• Iodine (administration & dosage, deficiency, urine)
• Legislation, Medical
• Male
• Public Health
• Reproducibility of Results
• Sodium Chloride, Dietary (administration & dosage)
• Thyroid Gland (diagnostic imaging, pathology)
• Turkey (epidemiology)
• Ultrasonography