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Determination of iodine concentration in urine by isotope dilution analysis and thyroid volume of school children in the west coast of Turkey after mandatory salt iodization.

AbstractOBJECTIVE:
This study was designed to evaluate iodine deficiency status in children 6-12 years in the west coast (Aegean Region) of Turkey after 5 years of mandatory iodine prophylaxis. A total of 2300 children from 72 populations (rural and urban area) were evaluated with urinary iodine excretion and thyroid volume.
DESIGN:
Cross-sectional, observational study designed and performed according to surveillance methods for iodine deficiency disease (IDD) prevalence recommended by WHO/UNICEF/ICCIDD.
SUBJECTS:
The study population consisted of 2300 school children age ranging from 6 to 12 years. The children were selected by multiple stage randomization from 91 primary schools of 76 zones (91 clusters). Information about the use of iodized salt was obtained from the families.
MEASUREMENTS:
Data on the following were collected: birth date, sex, weight, height, thyroid size by palpation and ultrasonography; and urinary iodine by isotope dilution analysis method. Thyroid volumes above 97th percentile according to the WHO/ICCIDD by age and body surface area (BSA) were accepted as goitre.
RESULTS:
Iodized salt consumption was 51.7%. The prevalence of goitre determined by palpation was 12.1% and by ultrasound based on BSA and age were 9.8% and 5.5%, respectively. Median urinary iodine was 53 (2-142) microg/l.
CONCLUSION:
Mild to severe degree of iodine deficiency was detected in the west coast of Turkey.
AuthorsSükran Darcan, Perihan Unak, Osman Yalman, Fatma Yurt Lambrecht, F Zümrüt Biber, Damla Göksen, Mahmut Coker
JournalClinical endocrinology (Clin Endocrinol (Oxf)) Vol. 63 Issue 5 Pg. 543-8 (Nov 2005) ISSN: 0300-0664 [Print] England
PMID16268807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Sodium Chloride, Dietary
  • iodized salt
  • Iodine
Topics
  • Chi-Square Distribution
  • Child
  • Cross-Sectional Studies
  • Female
  • Goiter, Endemic (diagnosis, epidemiology, prevention & control)
  • Humans
  • Indicator Dilution Techniques
  • Iodine (administration & dosage, deficiency, urine)
  • Legislation, Medical
  • Male
  • Public Health
  • Reproducibility of Results
  • Sodium Chloride, Dietary (administration & dosage)
  • Thyroid Gland (pathology, ultrasonography)
  • Turkey (epidemiology)

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