Abstract | AIM: METHODS: RESULTS: After exposing to 64 mmol x L(-1) sodium azide for 4 hours, cell viability and MMP of SH-SY5Y cells significantly decreased. When pretreated with salidroside, the cell damage was greatly reduced and the mitochondrial membrane potential was maintained. Furthermore, salidroside can protect function of rat brain mitochondria against damage induced by sodium azide. CONCLUSION:
Salidroside was demonstrated to play an important role in improving the function of mitochondria.
|
Authors | Li-li Cao, Guan-hua Du, Min-wei Wang |
Journal | Yao xue xue bao = Acta pharmaceutica Sinica
(Yao Xue Xue Bao)
Vol. 40
Issue 8
Pg. 700-4
(Aug 2005)
ISSN: 0513-4870 [Print] China |
PMID | 16268503
(Publication Type: Journal Article)
|
Chemical References |
- Glucosides
- Phenols
- Sodium Azide
- rhodioloside
|
Topics |
- Animals
- Brain Neoplasms
(pathology, physiopathology)
- Cell Line, Tumor
- Cell Survival
- Glucosides
(isolation & purification, pharmacology)
- Humans
- Male
- Membrane Potentials
(drug effects)
- Mitochondria
(drug effects, metabolism)
- Neuroblastoma
(pathology, physiopathology)
- Oxidation-Reduction
(drug effects)
- Phenols
(isolation & purification, pharmacology)
- Plants, Medicinal
(chemistry)
- Rats
- Rats, Sprague-Dawley
- Rhodiola
(chemistry)
- Sodium Azide
|