Effectiveness of low-dose colestipol therapy in patients with moderate hypercholesterolemia.

Abstract

Recommended doses of bile-acid binding resins have an established hypocholesterolemic effect, but data on responses to low doses, especially in women and subjects with moderate hypercholesterolemia, are sparse. A double-blind, placebo-controlled, randomized trial of 3 low doses of colestipol hydrochloride was conducted in women and men with moderate hypercholesterolemia. Men and women with plasma low-density lipoprotein (LDL) cholesterol concentrations greater than 4 mmol/liter (155 mg/dl) and triglyceride concentrations less than 2.82 mmol/liter (250 mg/dl) were recruited for the study. Eligible patients (54 women and 98 men) were placed on the American Heart Association step I diet 6 weeks before randomization. Participants were subsequently assigned to 1 of 4 drug treatment groups (placebo, and 5, 10 and 15 g/day of colestipol in 2 divided doses) for an additional 12 weeks. Of the 152 patients randomized, 141 completed all aspects of the study. For the treatment groups--placebo, and 5, 10 and 15 g of colestipol--LDL cholesterol reductions (mmol/liter) were observed respectively (n = 141): 0.10 +/- 0.49 (2.7%), 0.65 +/- 0.41 (16.3%), 0.98 +/- 0.36 (22.8%) and 1.17 +/- 0.47 (27.2%) (p less than 0.001). Similar changes were observed in total cholesterol and apolipoprotein B concentrations. The apolipoprotein B/LDL cholesterol ratio increased significantly with increasing colestipol dosage. Modest but insignificant changes in plasma triglyceride levels occurred, and high-density lipoprotein cholesterol levels remained unchanged. A dose of 5 g/day of colestipol achieved 51% of the LDL cholesterol reduction noted with 15 g/day. Low-dose colestipol therapy is effective in the treatment of patients with moderate hypercholesterolemia.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: H R Superko, P Greenland, R A Manchester, N A Andreadis, G Schectman, N H West, D Hunninghake, W L Haskell, J L Probstfield
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 70 Issue 2 Pg. 135-40 (Jul 15 1992) ISSN: 0002-9149 [Print] United States
• PMID: 1626496 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Lipoproteins
• Triglycerides
• Cholesterol
• Colestipol

Topics

• Adult
• Cholesterol (blood)
• Colestipol (administration & dosage, adverse effects)
• Double-Blind Method
• Drug Evaluation
• Female
• Humans
• Hypercholesterolemia (blood, drug therapy)
• Lipoproteins (blood, drug effects)
• Male
• Middle Aged
• Triglycerides (blood)
• United States