99mTc-HL91 is inferior to 201Tl in scintigraphic detection of chronic myocardial ischaemia.

Abstract

AIM:

99mTc-HL91 is a new hypoxia agent and can identify acutely ischaemic viable myocardium in a canine model using a standard gamma camera. The purpose of the study was to determine whether this tracer could be used to detect regional ischaemia in chronic ischaemic myocardium in a swine model.

METHOD:

Using a porcine model of chronic myocardial ischaemia, five mini-pigs with proximal left anterior descending artery (LAD) stenoses were studied. Injection of 462.5 MBq (12.5 mCi) 99mTc-HL91 was followed by imaging over 2 h. Coronary angiography and dipyridamole stress-re-injection 201Tl single photon emission computed tomography (SPECT) were performed within 1 day of each other.

RESULTS:

None of the five pigs demonstrated positive hot 99mTc-HL91 uptake throughout the 2 h imaging, whereas four of the five animals showed significant myocardial ischaemia on 201Tl SPECT. The region of interest analysis of LAD/left circumflex artery count ratios at 1 and 2 h demonstrated similar 99mTc-HL91 uptake and retention in chronic ischaemic as well as non-ischaemic myocardium.

CONCLUSION:

99mTc-HL91 is inferior to 201Tl in scintigraphic detection of chronic myocardial ischaemia.

• Authors: Yen-Wen Wu, Chii-Ming Lee, Yi-Hwen Huang, Nai-Kuan Chou, Ruoh-Fen Yen, Kai-Yuan Tzen, Por-Jau Huang
• Journal: Nuclear medicine communications (Nucl Med Commun) Vol. 26 Issue 12 Pg. 1119-23 (Dec 2005) ISSN: 0143-3636 [Print] England
• PMID: 16264360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Organotechnetium Compounds
• Oximes
• Radiopharmaceuticals
• Thallium Radioisotopes
• technetium Tc 99m 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime

Topics

• Angiography
• Animals
• Coronary Angiography
• Echocardiography
• Ischemia (pathology)
• Myocardial Ischemia (diagnosis, pathology)
• Myocardium (pathology)
• Organotechnetium Compounds
• Oximes
• Radionuclide Imaging (instrumentation, methods)
• Radiopharmaceuticals
• Swine
• Swine, Miniature
• Thallium Radioisotopes
• Time Factors
• Tomography, Emission-Computed, Single-Photon (methods)