Abstract |
Imaging with technetium-99m methylene diphosphonate (99mTc-MDP) is established in the diagnosis of infection, neoplasia and ischaemic necrosis in orthopaedic practice, but its role in fracture healing is less well-defined. Previous studies have shown a relationship between fracture site activity (region A), activity in adjacent normal bone (region C) and time to union. The predictive value of the A/C ratio of the image obtained 300-800 s after injection was assessed in a prospective study of 50 patients with closed tibial fractures managed with plaster casts, external fixators and intramedullary nails. There were significant differences in absolute uptake and A/C ratio between the three groups (P less than 0.05), but this was not related to time to union. Reamed nailing alters the distribution of 99m-Tc-MDP uptake so as to reduce the A/C ratio (1.10 +/- 0.20), but there is a promising role for early phase bone scanning in non-operative (A/C = 1.40 +/- 0.21) or externally fixed (A/C = 1.26 +/- 0.22) fractures in conjunction with other non-invasive methods of monitoring the biomechanical environment.
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Authors | A L Wallace, R K Strachan, A Blane, J J Best, S P Hughes |
Journal | Skeletal radiology
(Skeletal Radiol)
Vol. 21
Issue 4
Pg. 241-5
( 1992)
ISSN: 0364-2348 [Print] Germany |
PMID | 1626291
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Technetium Tc 99m Medronate
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Topics |
- Adolescent
- Adult
- Aged
- Female
- Humans
- Male
- Middle Aged
- Radionuclide Imaging
- Retrospective Studies
- Technetium Tc 99m Medronate
- Tibial Fractures
(diagnostic imaging, surgery)
- Wound Healing
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