A pilot trial evaluating Meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia.

Abstract

The aim of this open-label, 8-week observational trial was to investigate the efficacy of Meta050 (a proprietary, standardized combination of reduced iso-alpha-acids from hops, rosemary extract and oleanolic acid) on pain in patients with rheumatic disease. Osteoarthritis, rheumatoid arthritis and fibromyalgia patients were given 440 mg Meta050 three times a day for 4 weeks, which was changed to 880 mg twice a day for the subsequent 4 weeks in the majority of patients. Pain and condition-specific symptoms were assessed using a standard visual analog scale (VAS), an abridged arthritis impact measurement scale (AIMS2) and the fibromyalgia impact questionnaire. Fifty-four subjects with rheumatic disease completed the trial. Following treatment, a statistically significant decrease in pain of 50% and 40% was observed in arthritis subjects using the VAS (p < 0.0001; Wilcoxon-ranked sums) and AIMS2 (p < 0.0001), respectively. Fibromyalgia subject scores did not significantly improve. A decreasing trend of C-reactive protein, a marker for inflammation, was also observed in those subjects who presented with elevated C-reactive protein. No serious side effects were observed. These observations suggest that Meta050 at a dosage of 440 mg three times a day has a beneficial effect on pain in arthritis subjects.

• Authors: Daniel Lukaczer, Gary Darland, Matthew Tripp, DeAnn Liska, Robert H Lerman, Barbara Schiltz, Jeffrey S Bland
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 19 Issue 10 Pg. 864-9 (Oct 2005) ISSN: 0951-418X [Print] England
• PMID: 16261517 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2005 John Wiley & Sons, Ltd.

Chemical References

• Antirheumatic Agents
• Plant Extracts
• Oleanolic Acid

Topics

• Administration, Oral
• Adolescent
• Adult
• Aged
• Antirheumatic Agents (administration & dosage, therapeutic use)
• Arthritis, Rheumatoid (drug therapy, pathology)
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Fibromyalgia (drug therapy, pathology)
• Humans
• Humulus
• Male
• Middle Aged
• Olea
• Oleanolic Acid (administration & dosage, therapeutic use)
• Osteoarthritis (drug therapy, pathology)
• Pain Measurement
• Phytotherapy
• Pilot Projects
• Plant Extracts (administration & dosage, therapeutic use)
• Rosmarinus
• Severity of Illness Index
• Surveys and Questionnaires
• Treatment Outcome