[Histological study of livers from the patients with chronic hepatitis B treated with bicyclol].

Abstract

OBJECTIVE:

To study histological changes of the livers in patients with chronic viral hepatitis B treated with bicyclol tablets.

METHODS:

Thirty one patients with chronic viral hepatitis B were divided into two groups and were treated with bicyclol orally at doses of 150 mg daily or 75 mg daily for 36 weeds. The histological changes of the livers were observed before and after the treatment.

RESULTS:

Compared with pre-treatment findings, there were significant differences in histological activity index in each group (P < 0.01, P < 0.05), there were also significant differences between the two groups (P < 0.05). Decreased inflammatory reaction was also seen (P < 0.05).

CONCLUSION:

Daily use of 150 mg and 75 mg bicyclol tablets are effective in improving liver histological changes in chronic hepatitis B patients. Bicyclol 150 mg daily was better.

• Authors: Rui-dan Zheng, Zheng Yang, Cheng-run Xu, Hai-dong Zhao
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 19 Issue 3 Pg. 293-4 (Sep 2005) ISSN: 1003-9279 [Print] China
• PMID: 16261220 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Antiviral Agents
• Biphenyl Compounds
• DNA, Viral
• Hepatitis B Antibodies
• Hepatitis B e Antigens
• Tablets
• bicyclol

Topics

• Adult
• Antiviral Agents (therapeutic use)
• Biphenyl Compounds (therapeutic use)
• DNA, Viral (blood, genetics)
• Female
• Hepatitis B Antibodies (blood, immunology)
• Hepatitis B e Antigens (immunology)
• Hepatitis B virus (drug effects, genetics, immunology)
• Hepatitis B, Chronic (blood, drug therapy, virology)
• Humans
• Liver (drug effects, pathology, virology)
• Male
• Middle Aged
• Tablets
• Treatment Outcome
• Young Adult