Severe hemolytic disease of the newborn due to anti-Cw.

Abstract

BACKGROUND:

Pregnancies complicated by Rh isoimmunization have decreased significantly since the widespread use of Rh immune globulin. Uncommon red blood cell antigens have therefore become more clinically evident. We report a case of anti-Cw immunization that resulted in severe fetal anemia that required multiple transfusions.

CASE:

A 28-year-old multigravida presented to our service at 18 weeks of gestation with her fourth pregnancy. Her pregnancy was complicated by anti-Cw isoimmunization that resulted in severe fetal anemia requiring in utero fetal blood transfusions.

CONCLUSION:

While previous reports recommend only postpartum surveillance when Cw isoimmunization is present, we report a case resulting in severe fetal anemia.

• Authors: Benjamin D Byers, Michael C Gordon, Kenneth Higby
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 106 Issue 5 Pt 2 Pg. 1180-2 (Nov 2005) ISSN: 0029-7844 [Print] United States
• PMID: 16260563 (Publication Type: Case Reports, Journal Article)

Chemical References

• Isoantibodies
• anti-c antibody

Topics

• Adult
• Anemia, Neonatal (etiology, therapy)
• Blood Group Incompatibility (complications)
• Blood Transfusion (methods)
• Blood Transfusion, Intrauterine (methods)
• Erythroblastosis, Fetal (etiology, therapy)
• Female
• Humans
• Infant, Newborn
• Isoantibodies (blood)
• Postpartum Period
• Pregnancy
• Pregnancy Outcome
• Rh Isoimmunization (complications)