HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Immunohistochemical analysis of ras oncogene p21 product in human gastric carcinomas and their adjacent mucosas.

Abstract
In an attempt to clarify the relationship between ras oncogene expression and the clinico-pathological features of malignant and pre-malignant lesions of the stomach we undertook the immunohistochemical study of the expression of ras gene p21 product in a series of eighty gastric carcinomas and their respective adjacent mucosas. In two cases the mRNA of Ha-ras was also studied by in situ hybridization. The majority of gastric carcinomas as well as their adjacent non-neoplastic mucosas expressed ras gene product. There was a significant relationship between the expression of ras gene p21 product and the morphologic pattern of the tumours. An enhanced ras expression was found in several conditions regarded as precursor lesions of intestinal and/or diffuse types of gastric carcinoma (dysplasia, foveolar hyperplasia and even the neck zone of normal-appearing gastric glands, namely in the mucosa adjacent to diffuse carcinomas). Ras expression was actually more prominent in most of these conditions than in their respective adjacent carcinomas. No significant relationship was found between ras expression and invasiveness of the wall, nodal metastases and venous invasion.
AuthorsF Carneiro, L David, C Sunkel, C Lopes, M Sobrinho-Simões
JournalPathology, research and practice (Pathol Res Pract) Vol. 188 Issue 3 Pg. 263-72 (Apr 1992) ISSN: 0344-0338 [Print] GERMANY
PMID1625989 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Neoplasm
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)
Topics
  • DNA, Neoplasm (genetics)
  • Gastric Mucosa (chemistry)
  • Humans
  • Immunoenzyme Techniques
  • Nucleic Acid Hybridization
  • Proto-Oncogene Proteins p21(ras) (analysis)
  • Retrospective Studies
  • Stomach Neoplasms (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: