(1) The influence of the time of administration of antidotal treatment consisting of
anticholinergic drug (
atropine) and newly developed
oxime (K027 or K048) on its effectiveness to eliminate
tabun-induced lethal toxic effects was studied in mice. (2) The therapeutic efficacy of antidotal treatment of
tabun-induced acute
poisoning depends on the time of its administration regardless of the choice of the
oxime. (3) Our results show that both
oximes studied (K027, K048) are able to sufficiently eliminate lethal effects of
tabun. Nevertheless, their efficacy significantly decreases when they were administered 5 min after
tabun poisoning. (4) The findings support the hypothesis that both newly developed
oximes appear to be suitable
oximes to counteract acute toxicity of
tabun although their ability to eliminate lethal toxic effects of
tabun significantly decreases with prolonged time interval between
tabun challenge and antidotal treatment administration.