Abstract | PURPOSE: METHODS: RESULTS: The microsatellite-unstable group showed significantly higher expression of heat shock protein 70 than the microsatellite-stable group (P = 0.006), and patients undergoing curative resections for unstable cancers had improved prognosis compared with their stable counterparts (P = 0.026). Significantly, in a multivariate survival analysis, low or absent heat shock protein 70 expression was independently associated with a poor outcome (P = 0.001). CONCLUSIONS:
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Authors | Ayan Banerjea, Roger M Feakins, Carole D Nickols, Simon M Phillips, Michael P Powar, Stephen A Bustin, Sina Dorudi |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 48
Issue 12
Pg. 2322-8
(Dec 2005)
ISSN: 0012-3706 [Print] United States |
PMID | 16258706
(Publication Type: Journal Article)
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Chemical References |
- HSP70 Heat-Shock Proteins
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Topics |
- Age Factors
- Aged
- Case-Control Studies
- Colonic Neoplasms
(genetics)
- Female
- Gene Expression Profiling
- Genomic Instability
- HSP70 Heat-Shock Proteins
(biosynthesis, genetics)
- Humans
- Immunohistochemistry
- Male
- Microsatellite Repeats
(genetics)
- Middle Aged
- Multivariate Analysis
- Neoplasm Staging
- Prognosis
- Survival Analysis
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