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[Renoprotective effect of iptakalim hydrochloride in hypertension].

AbstractOBJECTIVE:
To investigate the experimental therapeutic effects of iptakalim hydrochloride (Ipt) on renoprotection in spontaneously hypertensive rats.
METHODS:
30 SHR were treated ig with Ipt 1, 3, 9 mg.kg(-1).d(-1), benazepril 3 mg.kg(-1).d(-1) once a day for 12 weeks. Age-matched WKY rats were used as normal control. The blood pressure, heart rates, proteinuria were assessed, and renal tissues were examined by light microscopy. The levels of blood and renal tissue ET-1 and TGF-beta1 were detected respectively by radioimmunoanalysis and enzyme linked immune absorption assay (ELISA).
RESULTS:
During 12 weeks experimental period, the systolic blood pressure (SBP) and heart rates (HR) of the untreated SHR were increased progressively. Ipt (3, 9 mg.kg(-1).d(-1)) could decrease effectively and inhibit the increasing tendency of HR. In addition, Ipt (1, 3, 9 mg.kg(-1).d(-1)) reduced urinary proteinuria, alleviated obviously the small vascular remodeling of renal and decreased the levels blood and renal ET-1 and TGF-beta1. Ipt (3, 9 mg.kg(-1).d(-1)) alleviated obviously the small vascular remodeling of renal compared with Ipt (1 mg.kg(-1).d(-1)).
CONCLUSIONS:
Ipt (1, 3, 9 mg.kg(-1).d(-1)) decreased SBP and protected the kidney of SHR. The renoprotection of Ipt may be involved in inhibiting of blood and renal tissue ET-1 and TGF-beta1.
AuthorsHao Xue, Guo-shu Liu, Hai Wang
JournalZhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 44 Issue 10 Pg. 769-72 (Oct 2005) ISSN: 0578-1426 [Print] China
PMID16255889 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antihypertensive Agents
  • Endothelin-1
  • N-(1-methylethyl)-1,1,2-trimethylpropylamine
  • Propylamines
  • Transforming Growth Factor beta
Topics
  • Animals
  • Antihypertensive Agents (pharmacology)
  • Blood Pressure (drug effects)
  • Dose-Response Relationship, Drug
  • Endothelin-1 (metabolism)
  • Female
  • Heart Rate (drug effects)
  • Hypertension (drug therapy)
  • Kidney (drug effects)
  • Male
  • Propylamines (pharmacology)
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Transforming Growth Factor beta (metabolism)

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