Abstract | PURPOSE: MATERIALS AND METHODS: Effectiveness data from a meta-analysis of 9 randomized trials (N=435) were used to populate a decision model to estimate the cost-effectiveness of Pentaglobin and its comparator standard therapy from the hospital perspective in Germany. PRIMARY OUTCOME: all-cause morality; secondary outcome: intensive care unit (ICU) length of stay. Benefit was expressed as lives saved (LS). Published cost data were applied to assess differences in ICU treatment costs. Cost-effectiveness was calculated as incremental cost per LS. RESULTS:
Pentaglobin reduced the risk of mortality (P<.001) but had no effect on ICU length of stay. A baseline risk of mortality of 0.4434 (risk ratio=0.5652; absolute risk reduction=0.1928; number-needed-to-treat=5.19) increased ICU treatment costs with Pentaglobin by 2,037 (22,711 vs 24,747) with a cost per LS of 10,565. Sensitivity analyses on baseline mortality risk (95% confidence interval 0.3293-0.5162) and risk ratio (95% confidence interval 0.4306-0.7420) yielded a cost per LS range of 5,715 to 28,443 with a 56.3% probability of cost-effectiveness of 12,000 or less. CONCLUSIONS:
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Authors | Aileen R Neilson, Hilmar Burchardi, Heinz Schneider |
Journal | Journal of critical care
(J Crit Care)
Vol. 20
Issue 3
Pg. 239-49
(Sep 2005)
ISSN: 0883-9441 [Print] United States |
PMID | 16253792
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin A
- Immunoglobulin M
- pentaglobulin
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Topics |
- Cost-Benefit Analysis
- Decision Support Techniques
- Drug Costs
- Germany
- Humans
- Immunoglobulin A
(economics, therapeutic use)
- Immunoglobulin M
(economics, therapeutic use)
- Intensive Care Units
- Length of Stay
- Sepsis
(drug therapy, economics, mortality)
- Shock, Septic
(drug therapy, economics, mortality)
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