An emerging role for PtdIns(4,5)P2-mediated signalling in human disease.

Abstract

Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2) appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome.

• Authors: Jonathan R Halstead, Kees Jalink, Nullin Divecha
• Journal: Trends in pharmacological sciences (Trends Pharmacol Sci) Vol. 26 Issue 12 Pg. 654-60 (Dec 2005) ISSN: 0165-6147 [Print] England
• PMID: 16253350 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Ion Channels
• Phosphatidylinositol 4,5-Diphosphate
• Phosphatidylinositol Phosphates

Topics

• Animals
• Bipolar Disorder (metabolism)
• Heart Diseases (metabolism)
• Humans
• Ion Channels (metabolism)
• Oculocerebrorenal Syndrome (metabolism)
• Phosphatidylinositol 4,5-Diphosphate
• Phosphatidylinositol Phosphates (metabolism)
• Signal Transduction