The effects of three oral sprays on plaque and gingival inflammation.

Abstract

BACKGROUND:

The aim of this clinical trial was to compare the effects of three oral sprays containing chlorhexidine (CHX), benzydamine hydrochloride (B-HCl), and CHX plus B-HCl (CHX/B-HCl) on plaque and gingivitis.

METHODS:

Fifty-one periodontally healthy volunteers, randomly divided into three spray groups, refrained from all mechanical oral hygiene measures for 7 days and, instead, used one of the randomly assigned sprays twice daily. The plaque index (PI), gingival index (GI), and gingival bleeding time index (GBTI) were assessed at days 0 and 7. Side effects were also evaluated.

RESULTS:

In all groups, PI, GI, and GBTI showed significant increases from the baseline to day 7. There were no significant side effects for B-HCl spray and CHX spray at day 7, but, for CHX/B-HCl, burning sensation significantly increased from the baseline. For all parameters, there were significant differences between B-HCl and CHX/B-HCl and between B-HCl and CHX, but no significant differences were observed between CHX/B-HCl and CHX. In addition, a significant difference was found between CHX/B-HCl and CHX with regard to burning sensation.

CONCLUSIONS:

These results indicate that both CHX and CHX/B-HCl sprays have equal clinical effectiveness, but only B-HCl spray has less anti-plaque and anti-gingivitis effects. Furthermore, CHX/B-HCl spray causes more side effects.

• Authors: F Yesim Bozkurt, Mine Oztürk, Zuhal Yetkin
• Journal: Journal of periodontology (J Periodontol) Vol. 76 Issue 10 Pg. 1654-60 (Oct 2005) ISSN: 0022-3492 [Print] United States
• PMID: 16253086 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Aerosols
• Anti-Infective Agents
• Anti-Inflammatory Agents
• Drug Combinations
• Benzydamine
• Chlorhexidine

Topics

• Adolescent
• Adult
• Aerosols (therapeutic use)
• Anti-Infective Agents (administration & dosage)
• Anti-Inflammatory Agents (administration & dosage)
• Benzydamine (administration & dosage)
• Chlorhexidine (administration & dosage)
• Dental Plaque (prevention & control)
• Dental Plaque Index
• Double-Blind Method
• Drug Combinations
• Female
• Gingivitis (prevention & control)
• Humans
• Male
• Periodontal Index