Analgesic action of alpha-adrenolytics in albino mice.

Abstract

The effect of alpha-adrenolytics: phenoxybenzamine, phentolamine, aceperone, dihydroegotamine, and yohimbine, was tested on reactivity to pain, and on the analgesic action of morphine and pethidine in albino mice. The compounds exert an analgesic effect by themselves, and potentiate the analgesic action of threshold doses of morphine and pethidine. The results seem to provide another proof that the cerbral noradrenaline neurons participate in central mechanisms of pain perception.

• Authors: I Zebrowska-Lupina
• Journal: Polish journal of pharmacology and pharmacy (Pol J Pharmacol Pharm) 1977 Mar-Apr Vol. 29 Issue 2 Pg. 101-9 ISSN: 0301-0244 [Print] Poland
• PMID: 16252 (Publication Type: Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Analgesics
• Butyrophenones
• Phenoxybenzamine
• Yohimbine
• Dihydroergotamine
• Morphine
• Meperidine
• Phentolamine

Topics

• Adrenergic alpha-Antagonists (pharmacology)
• Analgesics
• Animals
• Butyrophenones (pharmacology)
• Dihydroergotamine (pharmacology)
• Drug Synergism
• Electric Stimulation
• Hot Temperature
• Male
• Meperidine (pharmacology)
• Mice
• Morphine (pharmacology)
• Motor Activity (drug effects)
• Phenoxybenzamine (pharmacology)
• Phentolamine (pharmacology)
• Reaction Time (drug effects)
• Yohimbine (pharmacology)