Serum soluble transferrin receptor is a valuable diagnostic tool in iron deficiency of breath-holding spells.

Abstract

Iron-deficiency anemia may be a factor contributing to breath-holding spells. The serum transferrin receptor provides a useful measure of tissue iron deficiency. In this study of 50 breath-holders, while iron-deficiency anemia was detected in 28 (56%) of patients with routine tests, serum transferrin receptor levels were found increased in all patients. A positive correlation was detected between serum soluble transferrin receptor levels and frequency of attacks. It is suggested that the serum transferrin receptor level is useful as a single test for identification of iron deficiency in breath-holders. Moreover, if iron deficiency can be diagnosed earlier, then patients can be treated earlier.

• Authors: Uğur Handan, Cin Sükrü, Deda Gülhis, Gökçe Hafize, Elhan H Atilla, Akar Nejat
• Journal: Pediatric hematology and oncology (Pediatr Hematol Oncol) Vol. 22 Issue 8 Pg. 711-6 (Dec 2005) ISSN: 0888-0018 [Print] England
• PMID: 16251178 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ferrous Compounds
• Receptors, Transferrin
• ferrous sulfate

Topics

• Anemia, Iron-Deficiency (blood, complications, drug therapy)
• Apnea (blood, etiology)
• Child, Preschool
• Female
• Ferrous Compounds (administration & dosage, therapeutic use)
• Humans
• Infant
• Male
• Predictive Value of Tests
• Receptors, Transferrin (blood)
• Respiration Disorders (blood, complications, drug therapy)
• Solubility