Different gamma/delta T clones sustain GVM and GVH effects in multiple myeloma patients after non-myeloablative transplantation.

Abstract

TCR gamma/delta profiles were analyzed in 13 multiple myeloma patients after allogeneic non-myeloablative transplantation. Results show that both aGVHD and minimal residual disease (MRD) eradication did significantly affect TCR gamma/delta profile. During follow-up, six patients developed an aGVHD episode; in five of them, this event fitted with a modification of the TCR profile. Eleven patients achieved PCR-negativity during follow-up. In the 90% of them, the appearance of a new predominant TCR peak was concomitant to the disappearance of the IgH clone. These results suggest that different T gamma/delta populations would sustain GVM and GVH effects after non-myeloablative allogeneic transplant.

• Authors: Sara Galimberti, Edoardo Benedetti, Fortunato Morabito, Iacopo Petrini, Barbara Battolla, Federico Papineschi, Rita Fazzi, Elena Ciabatti, Massimo Martino, Mariella Cuzzola, Giuseppe Console, Pasquale Iacopino, Mario Petrini
• Journal: Leukemia research (Leuk Res) Vol. 30 Issue 5 Pg. 529-35 (May 2006) ISSN: 0145-2126 [Print] England
• PMID: 16249028 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin Heavy Chains
• Receptors, Antigen, T-Cell, gamma-delta

Topics

• Adult
• Aged
• Clone Cells
• Female
• Follow-Up Studies
• Graft vs Host Disease (genetics, immunology, therapy)
• Graft vs Tumor Effect (genetics, immunology)
• Humans
• Immunoglobulin Heavy Chains (genetics)
• Male
• Middle Aged
• Multiple Myeloma (genetics, immunology, therapy)
• Neoplasm, Residual (genetics, immunology, therapy)
• Peripheral Blood Stem Cell Transplantation (adverse effects, methods)
• Receptors, Antigen, T-Cell, gamma-delta (analysis, genetics)
• Transplantation, Homologous
• Treatment Outcome