Anti-IgE therapy in allergic asthma.

Abstract

Despite the advanced and increasing understanding of the pathophysiology of asthma and other allergic diseases, current treatment remains unspecific and targets late events within the allergic cascade. Therefore, a novel and promising approach to treat allergic asthma is antagonizing IgE by anti-IgE antibodies. This review analyzes the role of IgE for the pathology of asthma, summarize the current data about action, safety and efficacy of anti-IgE therapy, and tries to give a rational approach for future indications and directions of treatment with anti-IgE antibodies.

• Authors: Claudia Rolinck-Werninghaus, Ulrich Wahn, Eckard Hamelmann
• Journal: Current drug targets. Inflammation and allergy (Curr Drug Targets Inflamm Allergy) Vol. 4 Issue 5 Pg. 551-64 (Oct 2005) ISSN: 1568-010X [Print] Netherlands
• PMID: 16248824 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Anti-Idiotypic
• anti-IgE antibodies
• Immunoglobulin E

Topics

• Antibodies, Anti-Idiotypic (therapeutic use)
• Asthma (therapy)
• Food Hypersensitivity (therapy)
• Humans
• Immunoglobulin E (chemistry, physiology)
• Rhinitis, Allergic, Seasonal (therapy)