Abstract | BACKGROUND: OBJECTIVE: METHODS: We used immunohistochemistry and in situ hybridization to examine the expression of orexin, neuronal activity-regulated pentraxin (NARP), and prodynorphin in hypothalami from five control and two narcoleptic individuals. RESULTS: In the control hypothalami, at least 80% of the orexin-producing neurons also contained prodynorphin mRNA and NARP. In the patients with narcolepsy, the number of cells producing these markers was reduced to about 5 to 10% of normal. CONCLUSIONS:
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Authors | A Crocker, R A España, M Papadopoulou, C B Saper, J Faraco, T Sakurai, M Honda, E Mignot, T E Scammell |
Journal | Neurology
(Neurology)
Vol. 65
Issue 8
Pg. 1184-8
(Oct 25 2005)
ISSN: 1526-632X [Electronic] United States |
PMID | 16247044
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Autoantibodies
- Intracellular Signaling Peptides and Proteins
- Nerve Tissue Proteins
- Neuropeptides
- Orexins
- RNA, Messenger
- neuronal pentraxin
- Dynorphins
- C-Reactive Protein
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Topics |
- Aged
- Autoantibodies
(immunology)
- Autoimmune Diseases of the Nervous System
(complications, pathology, physiopathology)
- Brain Mapping
- C-Reactive Protein
(deficiency, genetics, immunology)
- Dynorphins
(deficiency, genetics, immunology)
- Humans
- Hypothalamus
(metabolism, pathology, physiopathology)
- Immunohistochemistry
- Intracellular Signaling Peptides and Proteins
(deficiency, genetics, immunology)
- Male
- Middle Aged
- Narcolepsy
(etiology, pathology, physiopathology)
- Nerve Degeneration
(genetics, pathology, physiopathology)
- Nerve Tissue Proteins
(deficiency, genetics, immunology)
- Neural Pathways
(metabolism, pathology, physiopathology)
- Neurodegenerative Diseases
(complications, pathology, physiopathology)
- Neurons
(metabolism, pathology)
- Neuropeptides
(deficiency, genetics, immunology)
- Orexins
- RNA, Messenger
(metabolism)
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