Efficacy and safety of the covered Wallstent in patients with distal malignant biliary obstruction.

Abstract

BACKGROUND:

The aim of this study was to evaluate the efficacy and the safety of the covered Wallstent, a commercially available silicone-covered, self-expandable metallic stent (covered Wallstent), for the treatment of distal malignant biliary obstruction.

METHODS:

Sixty-nine consecutive patients with unresectable distal malignant biliary obstruction who underwent covered Wallstent placement between October 2001 and October 2003 were studied at 4 affiliated hospitals.

RESULTS:

Mean stent patency and mean survival were 139.1 days and 200.9 days, respectively. Stent occlusion occurred in 7 cases (10.1%), but tumor ingrowth was not observed. Seventeen complications, including 5 cholangitis (7.2%), 4 stent migration (5.8%), 4 cholecystitis (5.8%), and 4 pancreatitis (5.8%) were observed in 16 patients (23.2%). Stent misplacement was observed in 7 patients (10.1%).

CONCLUSIONS:

Covered Wallstent is effective in preventing tumor ingrowth for the treatment of distal malignant biliary obstruction. However, the overall complication rate may be higher than uncovered self-expanding metal stents and covered self-expanding metal stents of different design.

• Authors: Yousuke Nakai, Hiroyuki Isayama, Yutaka Komatsu, Takeshi Tsujino, Nobuo Toda, Naoki Sasahira, Natsuyo Yamamoto, Kenji Hirano, Minoru Tada, Haruhiko Yoshida, Takao Kawabe, Masao Omata
• Journal: Gastrointestinal endoscopy (Gastrointest Endosc) Vol. 62 Issue 5 Pg. 742-8 (Nov 2005) ISSN: 0016-5107 [Print] United States
• PMID: 16246690 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Coated Materials, Biocompatible
• Silicones

Topics

• Adult
• Aged
• Aged, 80 and over
• Biliary Tract Neoplasms (complications)
• Cholestasis, Extrahepatic (etiology, surgery)
• Coated Materials, Biocompatible
• Common Bile Duct Diseases (etiology, surgery)
• Endoscopy, Digestive System
• Female
• Humans
• Male
• Middle Aged
• Pancreatic Neoplasms (complications)
• Silicones
• Stents (adverse effects)