Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression.

Abstract

BACKGROUND:

The POU-domain transcription factor Oct-6 has been reported to be differentially expressed between schizophrenic and control post-mortem brains. In this study, we attempted to replicate this finding and to discover whether Oct-6 was also dysregulated in bipolar disorder and major depression.

METHODS:

Oct-6 mRNA and protein expression were determined by in-situ hybridization and immunohistochemistry respectively in sections of post-mortem brain.

RESULTS:

We did not observe any differences in Oct-6 expression between any of the groups under study. Oct-6 mRNA and protein was identically expressed in the hippocampal and cortical regions of most specimens in all groups, including controls.

CONCLUSION:

Oct-6 is, therefore, unlikely to be a specific marker for any psychological disorder; rather its expression in controls suggests that it is normally expressed in most adult brains.

• Authors: Kirenjeet Ubhi, Jack Price
• Journal: BMC psychiatry (BMC Psychiatry) Vol. 5 Pg. 38 (Oct 24 2005) ISSN: 1471-244X [Electronic] England
• PMID: 16246257 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• RNA, Messenger
• Octamer Transcription Factor-6

Topics

• Adult
• Biomarkers
• Bipolar Disorder (genetics, metabolism)
• Brain Chemistry
• Cause of Death
• Cerebral Cortex (metabolism)
• Depressive Disorder, Major (genetics, metabolism)
• Female
• Frozen Sections
• Gene Expression
• Hippocampus (metabolism)
• Humans
• Immunohistochemistry
• In Situ Hybridization
• Male
• Middle Aged
• Octamer Transcription Factor-6 (genetics, metabolism)
• RNA, Messenger (genetics, metabolism)
• Schizophrenia (genetics, metabolism)