Structural characteristics of lysophosphatidic acid biological targets.

Abstract

Lysophosphatidic acid (LPA; 1-acyl-3-phosphoglycerol) exerts its biological activity through both extracellular and intracellular targets. Receptor targets include the cell-surface G-protein-coupled receptors LPA(1-4) and the nuclear PPAR-gamma (peroxisome-proliferator-activated receptor gamma). Enzyme targets include the secreted cancer cell motility factor, autotaxin, and the transmembrane phosphatases, LPP1-3 (where LPP stands for lipid phosphate phosphatase). Ion channel targets include the two pore domain ion channels in the TREK family, TREK-1, TREK-2 and TRAAK. Structural features of these targets and their interactions with LPA are reviewed.

• Authors: A L Parrill
• Journal: Biochemical Society transactions (Biochem Soc Trans) Vol. 33 Issue Pt 6 Pg. 1366-9 (Dec 2005) ISSN: 0300-5127 [Print] England
• PMID: 16246120 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Lysophospholipids
• PPAR gamma
• Potassium Channels, Tandem Pore Domain
• Protein Isoforms
• Receptors, Lysophosphatidic Acid
• potassium channel protein TREK-1
• lysophosphatidic acid

Topics

• Amino Acid Sequence
• Lysophospholipids (chemistry, metabolism)
• Models, Molecular
• Molecular Sequence Data
• PPAR gamma (metabolism)
• Potassium Channels, Tandem Pore Domain (chemistry, metabolism)
• Protein Conformation
• Protein Isoforms (metabolism)
• Receptors, Lysophosphatidic Acid (metabolism)
• Sequence Alignment