Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.

Abstract

Previously we found that 3,4-(methylenedioxy)-1-(2',3'-epoxypropyl)-benzene (safrole oxide) induced a typical apoptosis in A549 human lung cancer cells. In this study, we further investigated which caspases were activated by safrole oxide during the apoptosis. The data showed that the activity of caspase-3, -8, and -9 was significantly enhanced by the compound, which suggested that safrole oxide might be used as a caspase promoter to initiate lung cancer cell apoptosis.

• Authors: Aiying Du, Baoxiang Zhao, Deling Yin, Shangli Zhang, Junying Miao
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 16 Issue 1 Pg. 81-3 (Jan 01 2006) ISSN: 0960-894X [Print] England
• PMID: 16242324 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• safrole oxide
• CASP3 protein, human
• CASP6 protein, human
• CASP8 protein, human
• CASP9 protein, human
• Caspase 3
• Caspase 6
• Caspase 8
• Caspase 9
• Caspases
• Safrole

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Apoptosis
• Caspase 3
• Caspase 6
• Caspase 8
• Caspase 9
• Caspases (metabolism)
• Cell Line, Tumor
• Chemistry, Pharmaceutical (methods)
• Colorimetry
• Drug Design
• Humans
• Inflammation
• Lung Neoplasms (drug therapy, pathology)
• Models, Chemical
• Safrole (analogs & derivatives, pharmacology)
• Time Factors
• Up-Regulation