Abstract | OBJECTIVE: DESIGN: Prospective, randomized, controlled study. SUBJECTS: Forty-nine infertile women with a laparoscopic diagnosis of endometriosis stage I (n = 29) or II (n = 20) according to the revised American Fertility Society classification, randomly assigned to three superovulation cycles (n = 24) or 6 months' expectant management (n = 25). MAIN OUTCOME MEASURES: Cycle fecundity rates and cumulative pregnancy rates ( CPR) in the two groups. RESULTS: Nine pregnancies were obtained in the superovulation-treated patients and six in the nontreated ones. The cycle fecundity rates and CPR were 0.15% and 37.4% after three superovulation cycles and 0.045% and 24% after 6 months of expectant management (P less than 0.05 and P = not significant, respectively). The women who did not achieve a pregnancy after three cycles of superovulation were followed for a total of 50 months during which no therapy was given. One pregnancy started in this period (cycle fecundity rate = 0.020). One spontaneous abortion occurred in each group. Three treated patients had multiple pregnancies, and four had ovarian hyperstimulation syndrome. CONCLUSION: Superovulation seems to be associated with a better cycle fecundity rate but not a better CPR than expectant management in infertile women with endometriosis stages I and II. The efficacy and side effects of this therapeutic approach should be evaluated in larger series.
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Authors | L Fedele, S Bianchi, M Marchini, L Villa, D Brioschi, F Parazzini |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 58
Issue 1
Pg. 28-31
(Jul 1992)
ISSN: 0015-0282 [Print] United States |
PMID | 1624019
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Chorionic Gonadotropin
- Menotropins
- Buserelin
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Topics |
- Adult
- Buserelin
(pharmacology)
- Chorionic Gonadotropin
(pharmacology)
- Endometriosis
(complications, epidemiology)
- Female
- Humans
- Infertility, Female
(drug therapy, etiology)
- Menotropins
(adverse effects, pharmacology)
- Prospective Studies
- Superovulation
(drug effects)
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