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Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis: a controlled randomized study.

AbstractOBJECTIVE:
To determine the efficacy of superovulation with buserelin acetate, human menopausal gonadotropins (hMG), and human chorionic gonadotropin (hCG) in the treatment of infertility associated with minimal or mild endometriosis.
DESIGN:
Prospective, randomized, controlled study.
SUBJECTS:
Forty-nine infertile women with a laparoscopic diagnosis of endometriosis stage I (n = 29) or II (n = 20) according to the revised American Fertility Society classification, randomly assigned to three superovulation cycles (n = 24) or 6 months' expectant management (n = 25).
MAIN OUTCOME MEASURES:
Cycle fecundity rates and cumulative pregnancy rates (CPR) in the two groups.
RESULTS:
Nine pregnancies were obtained in the superovulation-treated patients and six in the nontreated ones. The cycle fecundity rates and CPR were 0.15% and 37.4% after three superovulation cycles and 0.045% and 24% after 6 months of expectant management (P less than 0.05 and P = not significant, respectively). The women who did not achieve a pregnancy after three cycles of superovulation were followed for a total of 50 months during which no therapy was given. One pregnancy started in this period (cycle fecundity rate = 0.020). One spontaneous abortion occurred in each group. Three treated patients had multiple pregnancies, and four had ovarian hyperstimulation syndrome.
CONCLUSION:
Superovulation seems to be associated with a better cycle fecundity rate but not a better CPR than expectant management in infertile women with endometriosis stages I and II. The efficacy and side effects of this therapeutic approach should be evaluated in larger series.
AuthorsL Fedele, S Bianchi, M Marchini, L Villa, D Brioschi, F Parazzini
JournalFertility and sterility (Fertil Steril) Vol. 58 Issue 1 Pg. 28-31 (Jul 1992) ISSN: 0015-0282 [Print] United States
PMID1624019 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Chorionic Gonadotropin
  • Menotropins
  • Buserelin
Topics
  • Adult
  • Buserelin (pharmacology)
  • Chorionic Gonadotropin (pharmacology)
  • Endometriosis (complications, epidemiology)
  • Female
  • Humans
  • Infertility, Female (drug therapy, etiology)
  • Menotropins (adverse effects, pharmacology)
  • Prospective Studies
  • Superovulation (drug effects)

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