Abstract | OBJECTIVE: DESIGN/SETTING: PATIENTS/PARTICIPANTS: INTERVENTIONS: Fasting serum between 8:00 A.M. and 9:00 A.M. Patients with hyperandrogenic chronic anovulation and CAH received dexamethasone (DEX) 2 mg for 7 days. MAIN OUTCOME MEASURES: RESULTS: Serum 11 beta-OHA and DHEAS were elevated in 52% and 40% of patients with hyperandrogenic chronic anovulation and in 7 of 7 and 1 of 7 patients with CAH. The ratio of A:11 beta-OHA was significantly higher (P less than 0.05) in hyperandrogenic chronic anovulation and significantly lower (P less than 0.05) in CAH compared with controls. Serum A:11 beta-OHA correlated with T (r = 0.58, P less than 0.05). The ratios of A:11 beta-OHA were similar and significantly lower in CAH and hyperandrogenic chronic anovulation patients who were DEX sensitive compared with those who were not DEX sensitive. The ratio correlated with the percentage suppression of T, unbound T, and A after DEX (P less than 0.01). There were no differences with measurements of DHEAS and 11 beta-OHA. Using the mean ratio of controls (1.3) as a cutoff value, the sensitivity of the A:11 beta-OHA in detecting adrenal hyperandrogenism, as assessed by DEX sensitivity, was 100%, the specificity was 84%, and the predictive value was 67%. CONCLUSIONS: The ratio of A:11 beta-OHA appears to be an excellent marker for identifying patients with adrenal hyperandrogenism and CAH.
|
Authors | E Carmina, F Z Stanczyk, L Chang, R A Miles, R A Lobo |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 58
Issue 1
Pg. 148-52
(Jul 1992)
ISSN: 0015-0282 [Print] United States |
PMID | 1623996
(Publication Type: Journal Article)
|
Chemical References |
- Androgens
- Biomarkers
- Androstenedione
- 11-hydroxyandrostenedione
- Dexamethasone
|
Topics |
- Adolescent
- Adrenal Gland Diseases
(blood, diagnosis)
- Adrenal Glands
(metabolism, pathology)
- Adrenal Hyperplasia, Congenital
- Adult
- Androgens
(metabolism)
- Androstenedione
(analogs & derivatives, blood)
- Biomarkers
(blood)
- Dexamethasone
(pharmacology)
- Female
- Humans
- Hyperplasia
(diagnosis, epidemiology, pathology)
- Prospective Studies
- Radioimmunoassay
|