Abstract | AIM: METHODS: Low-resolution DNA typing kit was used to determine HLA-DR-1 and -DQB1 genes in 72 patients with chronic hepatitis B (CHB) and HLA-DRB1 in 200 healthy people ready to donate their bone marrow in Shanghai. Among CHB patients, 35 were treated with IFNalpha-1b for 24 wk. RESULTS: The frequencies of HLA-DRB1*06, DRB1*08 and DRB1*16 alleles in 72 patients were higher than in 200 healthy people (2.08% vs 0%, OR = 3.837, P = 0.018; 11.11% vs 5.50%, OR = 2.148, P = 0.034; and 6.94% vs 3.00%, OR = 0.625, P = 0.049, respectively); whereas that of DRB1*07 allele was lower (2.78% vs 7.75%, OR = 0.340, P = 0.046). The frequency of HLA-DRB1* 14 allele was higher in 11 responders to IFN compared with 24 non-responders (18.18% vs 2.08%, OR = 10.444, P = 0.031), whereas that of DQB1*07 allele was inverse (9.09% vs 37.50%, OR = 0.167, P = 0.021). CONCLUSION: The polymorphism of HLA class II may influence the susceptibility to HBV infection and the response to IFN in studied CHB patients. Compared with other HLA-DRB1 alleles, HLA-DRB1*06, DRB1*08, and DRB1*16 may be associated with chronicity of HBV infection, HLA-DRB1*07 with protection against HBV infection, and HLA-DRB1*14 allele may be associated with a high rate of the response of CHB patients to IFN treatment. Compared with other HLA-DQB1 alleles, HLA-DQB1*07 may be associated with low response rate to IFN.
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Authors | Yong-Nian Han, Jin-Long Yang, Shui-Gen Zheng, Qun Tang, Wei Zhu |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 11
Issue 36
Pg. 5721-4
(Sep 28 2005)
ISSN: 1007-9327 [Print] United States |
PMID | 16237774
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DQB1 antigen
- HLA-DR Antigens
- HLA-DRB1 Chains
- Interferon-alpha
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Topics |
- Adult
- Antiviral Agents
(pharmacology, therapeutic use)
- Female
- Genetic Predisposition to Disease
(genetics)
- Genetic Variation
- Genotype
- HLA-DQ Antigens
(genetics)
- HLA-DQ beta-Chains
- HLA-DR Antigens
(genetics)
- HLA-DRB1 Chains
- Hepatitis B, Chronic
(drug therapy, genetics)
- Humans
- Interferon-alpha
(pharmacology, therapeutic use)
- Leukocytes
- Male
- Pharmacogenetics
- Treatment Outcome
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