Carcinogenic activity in Sprague-Dawley rats of 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-gluco-pyranose (chlorozotocin).

Abstract

Sprague--Dawley rats of both sexes received 2 mg/kg body wt (group 1) or 0.4 mg/kg body wt (group 2) of 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose (chlorozotocin) intraperitoneally in weekly injections for life. A dose-dependent carcinogenic effect of chlorozotocin was found (animals with malignant tumors in group 1: males 88%, females 89%, in group 2: males 83%, females 63%, in controls: males 10%, females 24%). Chlorozotocin reduced the life expectancy of treated animals significantly, compared to solvent controls. Histologically, the chlorozotocin-induced tumors were shown to be mesotheliomas or sarcomas of the peritoneal cavity (undifferentiated type, fibrosarcomas, myosarcomas).

• Authors: M Habs, G Eisenbrand, D Schmähl
• Journal: Cancer letters (Cancer Lett) Vol. 8 Issue 2 Pg. 133-7 (Dec 1979) ISSN: 0304-3835 [Print] Ireland
• PMID: 162366 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Carcinogens
• chlorozotocin
• Streptozocin

Topics

• Animals
• Antineoplastic Agents (adverse effects)
• Carcinogens
• Drug Evaluation, Preclinical
• Female
• Male
• Neoplasms, Experimental (chemically induced)
• Rats
• Streptozocin (adverse effects, analogs & derivatives)