Increased oxidative-related mechanisms in the spinal cord injury in old rats.

Abstract

In the present study, we evaluated the effect of age, in a model of spinal cord injury that was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. Spinal cord injury in old rats resulted in severe trauma characterized by edema and neutrophil infiltration. Immunohistochemical examination demonstrated an increase in immunoreactivity for nitrotyrosine. In contrast, the degree of: (a) spinal cord inflammation and tissue injury (histological score), (b) nitrotyrosine, (c) PARS, and (d) neutrophils infiltration was markedly reduced in spinal cord tissue obtained from young rats. We have also demonstrated that ageing significantly worsened the recovery of limb function and caused an increase in mortality rate when compared with young rats.

• Authors: Tiziana Genovese, Emanuela Mazzon, Rosanna Di Paola, Concetta Crisafulli, Carmelo Muià, Placido Bramanti, Salvatore Cuzzocrea
• Journal: Neuroscience letters (Neurosci Lett) Vol. 393 Issue 2-3 Pg. 141-6 (Jan 30 2006) ISSN: 0304-3940 [Print] Ireland
• PMID: 16236449 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Poly Adenosine Diphosphate Ribose
• 3-nitrotyrosine
• Tyrosine
• Peroxidase

Topics

• Age Factors
• Analysis of Variance
• Animals
• Disease Models, Animal
• Immunohistochemistry (methods)
• Laminectomy (methods)
• Male
• Oxidation-Reduction
• Peroxidase (metabolism)
• Poly Adenosine Diphosphate Ribose (metabolism)
• Rats
• Spinal Cord Injuries (metabolism, mortality)
• Time Factors
• Tyrosine (analogs & derivatives, metabolism)