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[Dilated cardiomyopathy and lipid-lowering drug muscle toxicity revealing late-onset Becker's disease].

AbstractINTRODUCTION:
The Becker's muscular dystrophy is a genetic myopathy due to mutations of the dystrophin gene, located in the Xp21 region, with a clinical expression usually occurring in young adults.
EXEGESIS:
We report an atypical case of late onset Becker's muscular dystrophy diagnosed at the age of 57. The patient suffered from mild skeletal muscle involvement revealed by the use of statins and fibrates, associated with severe dilating cardiomyopathy. The DNA analysis showed a deletion of the exons 11-13 in the Xp21 gene.
CONCLUSION:
The diagnostic of Becker's muscular dystrophy must be considered in all patients with persistently elevated CPK and/or primitive dilated cardiomyopathy, whatever the age of the patient.
AuthorsM A Vandenhende, F Bonnet, L Sailler, S Bouillot, P Morlat, J Beylot
JournalLa Revue de medecine interne (Rev Med Interne) Vol. 26 Issue 12 Pg. 977-9 (Dec 2005) ISSN: 0248-8663 [Print] France
Vernacular TitleCardiomyopathie dilatée et toxicité musculaire des hypolipémiants: une maladie de Becker de révélation tardive.
PMID16236395 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Hypolipidemic Agents
Topics
  • Age of Onset
  • Aged
  • Cardiomyopathy, Dilated (etiology)
  • Gene Deletion
  • Humans
  • Hypolipidemic Agents (adverse effects, therapeutic use)
  • Male
  • Muscle, Skeletal (drug effects, pathology)
  • Muscular Dystrophy, Duchenne (complications, diagnosis)

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