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The anticonvulsant effects of vitamin E: a further evaluation.

Abstract
Vitamin E (d-alpha-tocopherol) has proven to be a useful adjunct to anticonvulsant drugs in clinical studies. Improvement has occurred even in patients with complex partial seizures, which are often resistant to drug therapy. In animals, vitamin E is effective against ferrous chloride seizures, hyperbaric oxygen seizures and penicillin-induced seizures. It has failed, however, to show anticonvulsant effects in the standard animal models used for drug screening--the maximal electroshock and threshold pentylenetetrazol tests. The present experiments were designed to further explore the anti-epileptic actions of vitamin E in animals. Three models related to complex partial epilepsy were used: 1) the development of amygdala-kindled seizures; 2) the development of electrically-induced status in kindled animals; and 3) the development of kainic-acid seizures. Vitamin E failed to produce significant effects in any of the models.
AuthorsS L Levy, W M Burnham, A Bishai, P A Hwang
JournalThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (Can J Neurol Sci) Vol. 19 Issue 2 Pg. 201-3 (May 1992) ISSN: 0317-1671 [Print] England
PMID1623446 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticonvulsants
  • Ferrous Compounds
  • Penicillins
  • Vitamin E
  • ferrous chloride
  • Kainic Acid
Topics
  • Animals
  • Anticonvulsants (pharmacology)
  • Electrophysiology
  • Electroshock
  • Epilepsy, Complex Partial (prevention & control)
  • Ferrous Compounds
  • Hyperbaric Oxygenation
  • Kainic Acid
  • Kindling, Neurologic
  • Male
  • Penicillins
  • Rats
  • Seizures (chemically induced, prevention & control)
  • Vitamin E (pharmacology)

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