HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers.

AbstractAIMS:
Persons with high intake of polyunsaturated fatty acids (PUFAs) have lower cardiovascular morbidity and mortality. The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established.
METHODS AND RESULTS:
In 1123 persons (aged 20-98 yr), we examined the relationship between relative concentration of fatty acids in fasting plasma and level of inflammatory markers. Adjusting for age, sex, and major confounders, lower arachidonic and docosahexaenoic acids were associated with significantly higher IL-6 and IL-1ra and significantly lower TGFbeta. Lower alpha-linolenic acid was associated with higher C-reactive protein and IL-1ra, and lower eicosapentaenoic acid was associated with higher IL-6 and lower TGFbeta. Lower docosahexaenoic acid was strongly associated with lower IL-10. Total n-3 fatty acids were associated with lower IL-6 (P = 0.005), IL-1ra (P = 0.004), and TNFalpha (P = 0.040) and higher soluble IL-6r (P < 0.001), IL-10 (P = 0.024), and TGFbeta (P = 0.0012). Lower n-6 fatty acid levels were significantly associated with higher IL-1ra (P = 0.026) and lower TGFbeta (P = 0.014). The n-6 to n-3 ratio was a strong, negative correlate of IL-10. Findings were similar in participants free of cardiovascular diseases and after excluding lipids from covariates.
CONCLUSIONS:
In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Our findings support the notion that n-3 fatty acids may be beneficial in patients affected by diseases characterized by active inflammation.
AuthorsLuigi Ferrucci, Antonio Cherubini, Stefania Bandinelli, Benedetta Bartali, Annamaria Corsi, Fulvio Lauretani, Antonio Martin, Cristina Andres-Lacueva, Umberto Senin, Jack M Guralnik
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 91 Issue 2 Pg. 439-46 (Feb 2006) ISSN: 0021-972X [Print] United States
PMID16234304 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cytokines
  • Fatty Acids, Omega-3
  • Fatty Acids, Omega-6
  • Interleukin-1
  • Interleukin-6
  • Receptors, Interleukin-1
  • Receptors, Interleukin-6
  • Transforming Growth Factor beta
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • C-Reactive Protein
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • C-Reactive Protein (metabolism)
  • Cytokines (blood)
  • Diet
  • Fatty Acids, Omega-3 (administration & dosage, blood, metabolism)
  • Fatty Acids, Omega-6 (administration & dosage, blood, metabolism)
  • Female
  • Humans
  • Interleukin-1 (blood)
  • Interleukin-10 (blood)
  • Interleukin-6 (blood)
  • Italy
  • Male
  • Middle Aged
  • Receptors, Interleukin-1 (blood)
  • Receptors, Interleukin-6 (blood)
  • Transforming Growth Factor beta (blood)
  • Tumor Necrosis Factor-alpha (metabolism, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: