Anti-tumor properties of the organometallic complex cis-dimethylbis[sulfinylbis[methane]-S]platinum(II).

Abstract

The water-soluble organometallic complex cis-[Pt(Me)2(Me2SO)2] (Me = methyl; Me2SO = dimethyl sulfoxide) (cis-dimethyl platinum(II); CDMP) was evaluated for its toxicity on the rat and for its efficacy against two tumors of this animal: the Yoshida ascites sarcoma and the T8 sarcoma of Guérin. The lethal dose for 50% of normal animals was 46.4 mg/kg; the predominant toxic effects were loss of weight, decrease in leukocytes and necrosis of the kidneys after i.v. or of the liver after i.p. administration. Doses of drug varying from 2 to 40 mg/kg were administered once by i.p., i.v., i.m. and intra-tumor (i.t.) route from 1 to 7 days after i.p. injection of 10(6) Yoshida ascites sarcoma cells and s.c. implantation of approximately 300 mg of T8 sarcoma of Guérin. The compound showed anti-tumor activity increasing both the average life span and survival of the rats. A comparison between the therapeutic properties of the title complex with those of cis-[PtCl2(NH3)2] (CDDP) reveals that cis-dimethyl platinum(II) exhibits the same anti-tumor activity associated with 6 times reduced toxicity.

• Authors: V Fimiani, D Minniti
• Journal: Anti-cancer drugs (Anticancer Drugs) Vol. 3 Issue 1 Pg. 9-15 (Feb 1992) ISSN: 0959-4973 [Print] England
• PMID: 1623219 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Organoplatinum Compounds
• dimethylbis(sulfinylbis(methane)-S)platinum(II)
• Cisplatin

Topics

• Animals
• Cisplatin (therapeutic use, toxicity)
• Drug Screening Assays, Antitumor
• Female
• Kidney (drug effects)
• Lethal Dose 50
• Liver (drug effects)
• Male
• Organoplatinum Compounds (therapeutic use, toxicity)
• Rats
• Rats, Inbred Strains
• Sarcoma, Yoshida (drug therapy, mortality)
• Survival Rate