Abstract | BACKGROUND: METHODS: This study was conducted in 167 postmenopausal women, using data from the pre-randomization visit of an exercise clinical trial. Participants were sedentary, overweight/ obese, and not on hormone therapy. RESULTS:
DHEA-S concentrations were 42% higher, total testosterone concentrations were 35% lower, and free testosterone concentrations were 23% lower in women with both ovaries removed compared with those with both remaining (p = 0.01, p = 0.01, and p = 0.03, respectively). Women who had used herbal therapy in the past had, on average, 25% higher concentrations of total and free testosterone than women who had never used these herbal therapies (p = 0.03 and p = 0.004, respectively). No other significant associations were detected. CONCLUSIONS: Overall, this study does not support the hypothesis that reproductive or menstrual factors, with the exception of oophorectomy status, are associated with postmenopausal androgen concentrations.
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Authors | Jessica Chubak, Shelley S Tworoger, Yutaka Yasui, Cornelia M Ulrich, Frank Z Stanczyk, Anne McTiernan |
Journal | Journal of women's health (2002)
(J Womens Health (Larchmt))
Vol. 14
Issue 8
Pg. 704-12
(Oct 2005)
ISSN: 1540-9996 [Print] United States |
PMID | 16232102
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Gonadal Steroid Hormones
- Testosterone
- Androstenedione
- Dehydroepiandrosterone
- Dehydroepiandrosterone Sulfate
|
Topics |
- Aged
- Androstenedione
(blood)
- Confidence Intervals
- Dehydroepiandrosterone
(blood)
- Dehydroepiandrosterone Sulfate
(blood)
- Estrogen Replacement Therapy
- Exercise
- Female
- Gonadal Steroid Hormones
(blood)
- Health Status
- Humans
- Middle Aged
- Odds Ratio
- Phytotherapy
- Postmenopause
(metabolism)
- Testosterone
(blood)
- Time Factors
- Treatment Outcome
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