| Abstract | INTRODUCTION: Pathogenesis of sarcoidosis remains partially unknown. Cutaneous lesions are frequent (20 to 35% of cases). Their clinical features and follow-up data are highly variable. Numerous treatments have been proposed. The clinical features and follow up data of four patients with chronic cutaneous sarcoidosis treated with methotrexate are reported. CASE REPORT: Mean age of patients (3 female, 1 male) was 40 years old (34-49 years). One patient presented with a lupus pernio, two patients with papules and nodules, and the last with an annular lesion of the face. All patients had been previously treated with topical corticosteroids and/or hydroxychloroquine without any success. Patients were treated with methotrexate at doses ranging from 12.5 mg to 30 mg per week for at least 6 months. Complete remission of cutaneous lesions was observed in 3 of 4 patients after a mean treatment duration of 29 months (16 to 36). Methotrexate side effects were observed in one patient (elevated liver enzymes) leading to methotrexate discontinuation. DISCUSSION: Methotrexate seems to be an effective treatment of cutaneous sarcoidosis. It should be used namely in patients who failed to respond to previous treatments with topical corticosteroids or antimalarial drugs. |
| Authors | A Gary, A-B Modeste, C Richard, C Jubert, F Majour, G Nouvet, B Remond, P Joly
(Affiliation: Clinique Dermatologique, CHU de Rouen.)
|
| Journal | Annales de dermatologie et de vénéréologie
(Ann Dermatol Venereol)
2005 Aug-Sep
Vol. 132
Issue 8-9 Pt 1
Pg. 659-62
ISSN: 0151-9638 France |
| Vernacular Title | Traitement de la sarcoïdose cutanée par le méthotrexate: 4 observations. |
| PMID | 16230915
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Dermatologic Agents
- Methotrexate
|
| Topics |
- Adult
- Dermatologic Agents
(therapeutic use)
- Female
- Humans
- Male
- Methotrexate
(therapeutic use)
- Middle Aged
- Sarcoidosis
(drug therapy, pathology)
- Skin Diseases
(drug therapy, pathology)
- Treatment Outcome
|
