Feasibility and efficacy of arginine 2-mercaptoethanesulfonate (ARGIMESNA) in the prevention of hemorragic cystitis from ifosfamide (IFO).

Abstract

Tolerability and efficacy of the new uroprotective agent ARGIMESNA was assessed within a randomized cross-over study comparing it to sodiummercaptoethanesulfonate (MESNA), in patients treated with IFO. MESNA i.v., 20% of IFO dose, was given to all patients before chemotherapy; 4 h later, at random, they received ARGIMESNA p.o., 20% of IFO dose every 2 h x 4, or MESNA p.o., 40% of IFO dose every 4 h x 2. Overall, 78 cycles of oral uroprotection were administered: 37 for ARGIMESNA capsules; 41 for MESNA vials p.o. ARGIMESNA was subjectively better tolerated, determining gastro-intestinal discomfort in only 12 out of 37 cycles versus 34/41 of MESNA p.o. (p less than 0.001). Both preparations were equivalent for subjective and objective efficacy since no cycles were complicated by urinary symptoms (dysuria, stranguria, or hematuria). Nevertheless, 2 patients (7.7%) refused further oral assumption of both uroprotectors, whereas MESNA i.v. was added in other 7 patients because of nausea and vomiting caused by chemotherapy. In conclusion, this new oral preparation of mercaptoethanesulfonate turned out to be well tolerated, safe and active in the prevention of haemorrhagic cystitis from IFO.

• Authors: S Frustaci, S Foladore, A De Pascale, A Freschi, G Lo Re, R Sorio, D Errante, S Monfardini
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 3 Suppl 2 Pg. S115-8 (Apr 1992) ISSN: 0923-7534 [Print] England
• PMID: 1622852 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Mesna
• Ifosfamide

Topics

• Adolescent
• Adult
• Aged
• Cystitis (chemically induced, complications, prevention & control)
• Female
• Hemorrhage (chemically induced, etiology, prevention & control)
• Humans
• Ifosfamide (adverse effects, antagonists & inhibitors)
• Male
• Mesna (adverse effects, therapeutic use)
• Middle Aged