Field evaluation of the efficacy and safety of emodepside/praziquantel spot-on solution against naturally acquired nematode and cestode infections in domestic cats.

Abstract

Two controlled, blinded and randomized multi-site clinical field studies evaluated the efficacy and safety of emodepside/praziquantel spot-on in the treatment of gastrointestinal nematode and cestode infections in cats. In a study conducted in Europe, faecal egg count reductions of >98% for all nematode eggs and eggs of Toxocara cati, respectively, were observed in cats treated with emodepside/praziquantel spot-on (Profender, Bayer AG, Leverkusen, Germany). For a positive-control product containing selamectin (Stronghold) reductions of >95% were observed. A 100% reduction of faecal eggs and proglottids was observed in cats treated with emodepside/praziquantel spot-on that were infected with cestodes. In a study conducted in North America, cats were treated with either emodepside/praziquantel spot-on plus a placebo tablet or a combination of two control products containing, respectively, selamectin (Revolution) and epsiprantel (Cestex). Faecal egg count reduction for eggs of T. cati was >99% for both treatments. For faecal eggs and proglottids of Dipylidium caninum reductions of >99 and >97% were recorded for cats treated with emodepside/praziquantel spot-on and the control group, respectively. No adverse reactions were observed in the European study, and only mild ones of short duration in a few cats from both treatment groups of the North American study. The two studies demonstrated that emodepside/praziquantel spot-on is highly efficacious and safe under field conditions.

• Authors: G Altreuther, J Buch, S D Charles, W L Davis, K J Krieger, I Radeloff
• Journal: Parasitology research (Parasitol Res) Vol. 97 Suppl 1 Pg. S58-S64 (Oct 2005) ISSN: 1432-1955 [Electronic] Germany
• PMID: 16228276 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anthelmintics
• Depsipeptides
• Praziquantel
• emodepside

Topics

• Administration, Topical
• Animals
• Anthelmintics (administration & dosage, adverse effects, therapeutic use)
• Cat Diseases (drug therapy, parasitology)
• Cats
• Cestode Infections (drug therapy, veterinary)
• Depsipeptides (administration & dosage, adverse effects, therapeutic use)
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Nematode Infections (drug therapy, veterinary)
• Praziquantel (administration & dosage, adverse effects, therapeutic use)