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Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats.

Abstract
This paper reports the efficacy of emodepside/praziquantel spot-on (Profender), Bayer AG, Leverkusen, Germany), a novel broad-spectrum anthelmintic for dermal application, against L4 larvae and immature adult and adult stages of Ancylostoma tubaeforme in cats. The formulation contains 2.14% (w/w) emodepside and 8.58% (w/v) praziquantel, with emodepside being active against gastrointestinal nematodes and praziquantel against cestodes. Five randomized, blinded and controlled laboratory studies demonstrated 100% efficacy of emodepside/praziquantel spot-on against mature A. tubaeforme and an efficacy of >95% and >97%, respectively, against L4 larvae and immature adults (based on worm counts after necropsy) at approximately the minimum proposed dose rate in cats of 3.0 mg emodepside and 12.0 mg praziquantel/kg body weight. No adverse reactions to the treatment were observed. It is concluded that emodepside/praziquantel spot-on is an effective and safe treatment against infections with mature and immature A. tubaeforme. Emodepside/praziquantel spot-on will considerably facilitate the treatment of cats against nematodes and cestodes compared with orally administered preparations.
AuthorsG Altreuther, F H M Borgsteede, J Buch, S D Charles, L Cruthers, C Epe, D R Young, K J Krieger
JournalParasitology research (Parasitol Res) Vol. 97 Suppl 1 Pg. S51-S57 (Oct 2005) ISSN: 1432-1955 [Electronic] Germany
PMID16228275 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anthelmintics
  • Depsipeptides
  • Praziquantel
  • emodepside
Topics
  • Administration, Topical
  • Ancylostoma (drug effects)
  • Ancylostomiasis (drug therapy, veterinary)
  • Animals
  • Anthelmintics (administration & dosage, therapeutic use)
  • Cat Diseases (drug therapy, parasitology)
  • Cats
  • Depsipeptides (administration & dosage, therapeutic use)
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Praziquantel (administration & dosage, therapeutic use)

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