Abstract |
This paper reports the efficacy of emodepside/ praziquantel spot-on (Profender), Bayer AG, Leverkusen, Germany), a novel broad-spectrum anthelmintic for dermal application, against L4 larvae and immature adult and adult stages of Ancylostoma tubaeforme in cats. The formulation contains 2.14% (w/w) emodepside and 8.58% (w/v) praziquantel, with emodepside being active against gastrointestinal nematodes and praziquantel against cestodes. Five randomized, blinded and controlled laboratory studies demonstrated 100% efficacy of emodepside/ praziquantel spot-on against mature A. tubaeforme and an efficacy of >95% and >97%, respectively, against L4 larvae and immature adults (based on worm counts after necropsy) at approximately the minimum proposed dose rate in cats of 3.0 mg emodepside and 12.0 mg praziquantel/kg body weight. No adverse reactions to the treatment were observed. It is concluded that emodepside/ praziquantel spot-on is an effective and safe treatment against infections with mature and immature A. tubaeforme. Emodepside/ praziquantel spot-on will considerably facilitate the treatment of cats against nematodes and cestodes compared with orally administered preparations.
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Authors | G Altreuther, F H M Borgsteede, J Buch, S D Charles, L Cruthers, C Epe, D R Young, K J Krieger |
Journal | Parasitology research
(Parasitol Res)
Vol. 97 Suppl 1
Pg. S51-S57
(Oct 2005)
ISSN: 1432-1955 [Electronic] Germany |
PMID | 16228275
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anthelmintics
- Depsipeptides
- Praziquantel
- emodepside
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Topics |
- Administration, Topical
- Ancylostoma
(drug effects)
- Ancylostomiasis
(drug therapy, veterinary)
- Animals
- Anthelmintics
(administration & dosage, therapeutic use)
- Cat Diseases
(drug therapy, parasitology)
- Cats
- Depsipeptides
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Praziquantel
(administration & dosage, therapeutic use)
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