Abstract | BACKGROUND AND AIMS: Haeme oxygenase could play a role in the pathogenesis of arterial vasodilation in cirrhosis. The aim of this study was to verify the role of haeme oxygenase in the hyporesponsiveness to phenylephrine of small mesenteric arteries in rats with CCl(4) induced cirrhosis, with and without ascites. METHODS: RESULTS: CONCLUSION:
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Authors | M Bolognesi, D Sacerdoti, M Di Pascoli, P Angeli, S Quarta, A Sticca, P Pontisso, C Merkel, A Gatta |
Journal | Gut
(Gut)
Vol. 54
Issue 11
Pg. 1630-6
(Nov 2005)
ISSN: 0017-5749 [Print] England |
PMID | 16227362
(Publication Type: Journal Article)
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Chemical References |
- Enzyme Inhibitors
- Mesoporphyrins
- Vasoconstrictor Agents
- chromium mesoporphyrin
- Phenylephrine
- Nitric Oxide Synthase
- Heme Oxygenase (Decyclizing)
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Ascites
(physiopathology)
- Blotting, Western
- Dose-Response Relationship, Drug
- Drug Interactions
- Enzyme Inhibitors
(pharmacology)
- Heme Oxygenase (Decyclizing)
(physiology)
- Liver Cirrhosis, Experimental
(physiopathology)
- Male
- Mesenteric Arteries
(drug effects, physiopathology)
- Mesoporphyrins
(pharmacology)
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Nitric Oxide Synthase
(antagonists & inhibitors, physiology)
- Phenylephrine
(pharmacology)
- Rats
- Rats, Inbred WKY
- Tissue Culture Techniques
- Vasoconstriction
(drug effects)
- Vasoconstrictor Agents
(pharmacology)
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