Essiac, a
tea reportedly developed by the Ojibwa tribe of Canada and widely publicized as a homeopathic
cancer treatment, is prepared from a mixture of four herbs Arctium lappa, Rumex acetosella, Ulmus rubra and Rheum officinale. Each of these herbs has been reported to possess
antioxidant and anti-
cancer activity.
Essiac itself has also been reported to demonstrate anti-
cancer activity in vitro, although its effects in vivo are still a matter of debate. We prepared an extract of
Essiac tea from a concentration of 25mg/mL and boiled it for 10 min. From this preparation we used concentrations of 5, 10, 25 and 50% to measure
Essiac effects. In this study, we examined the effects of
Essiac on
free radical scavenging and DNA damage in a non-cellular system, as well as the effects
Essiac on lipid peroxidation using the RAW 264.7 cell line. We observed, using electron spin resonance, that
Essiac effectively scavenged
hydroxyl, up to 84% reduction in radical signal at the 50%
tea preparation concentration, and
superoxide radicals, up to 82% reduction in radical signal also at the 50%
tea preparation concentration, as well as prevented
hydroxyl radical-induced DNA damage. In addition,
Essiac inhibited
hydroxyl radical-induced lipid peroxidation by up to 50% at the 50%
tea preparation concentration. These data indicate that
Essiac tea possesses potent
antioxidant and
DNA-protective activity, properties that are common to natural anti-
cancer agents. This study may help to explain the mechanisms behind the reported anti-
cancer effects of
Essiac.